vancomycine

J - Antiinfectives For Systemic Use -> J01 - Antibacterials For Systemic Use -> J01X - Other Antibacterials -> J01XA - Glycopeptide Antibacterials -> J01XA01 - Vancomycin
Administration category: Free Medicine group: antibacterial

Safety margins

≥ 18 years
WeightROADosage
ROA:
po
Dosage:
min. 125mg 4 dd to max. 500mg 4 dd
Comments:

per os alleen bij pseudomembraneuze colitis

Standard dosages

≥ 18 years
WeightROALoadDosage
ROA:
iv
Load:
25mg/kg
Dosage:
20mg/kg 2 dd
ROA:
iv
Load:
30mg/kg
Dosage:
15mg/kg 3 dd
ROA:
iv
Load:
15mg/kg
Dosage:
40mg/kg continuous per 24 hours
ROA:
iv
Load:
20mg/kg
Dosage:
45mg/kg continuous per 24 hours
Comments:

Kidney function

≥ 18 years
ROAGFRDosageIntervalComments
ROA: iv
GFR:
50 - 80
Dosage:
15 mg/kg
Comments:
elke 12-24 uur, verder op geleide spiegels
GFR:
10 - 50
Dosage:
15 mg/kg
Comments:
meteen topspiegel meten alsook tweede spiegel binnen 24 u, verder op geleide van spiegels
GFR:
<10
Dosage:
15 mg/kg
Comments:
meteen topspiegel meten alsook tweede spiegel binnen 24 u, verder op geleide van spiegels
Renal elimination: 80%

Renal function-replacement therapy

CAPD: geen invloed, 15 mg/kg i.v. elke 4-7 dagen; intraperitoneaal diverse schema’s bijv. 2 g ip 1x/5-7 dagen of 1 dd 50 mg via CAPD zak voorafgegaan door een oplaaddosis.

Hemo dialysis: <70 kg: 1000 mg oplaaddosis gevolgd door 500 mg onderhoudsdosis. 70-100 kg: 1250 mg oplaadosis gevolgd door 750 mg onderhoudsdosis. >100 kg: 1500 mg oplaaddosis gevolgd door 1000 mg onderhoudsdosis.

CAV / VVHD: startdosering 15 mg/kg, verder op geleide spiegels

Interactions

Interaction with (ATC): Expected effect:
Interaction with (ATC):
J01G - Aminoglycoside Antibacterials
Expected effect:
toename nefrotoxiciteit

Pregnancy

Due to the expiration of the alphanumeric classification for use in pregnancy and lactation, reference is made to the current, online information of the Teratology Information Service (TIS) of LAREB:

For individual advice, consult an expert on site.

Comments

Metadata

Swab vid: M-1810.2
Updated: 07/20/2015 - 22:05
Status: Published

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